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TAN-67 (dihydrobromide)

CAT: 0804-HY-101317-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101317-01Size:5 mg
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Description
TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke[1][2].
CAS Number
1217628-73-3
Product Name Alternative
SB-205607 (dihydrobromide)
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tan-67-dihydrobromide.html
Purity
99.20
Solubility
10 mM in DMSO
Smiles
OC1=CC=CC([C@]23[C@@](CN(C)CC3)([H])CC4=CC5=CC=CC=C5N=C4C2)=C1.Br.Br
Molecular Formula
C23H26Br2N2O
Molecular Weight
506.27
References & Citations
[1]Knapp RJ, et, al. Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors. Eur J Pharmacol. 1995 Oct 15;291 (2) :129-34.|[2]Min JW, et, al. The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice. J Neurochem. 2018 Feb;144 (3) :336-347.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
δ Opioid Receptor/DOR

Chemical Information

SB 205607 dihydrobromide
CAS Number1217628-73-3
PubChem CID56972161
IUPAC Name3-[(4aS,12aR)-2-methyl-1,3,4,5,12,12a-hexahydropyrido[3,4-b]acridin-4a-yl]phenol;dihydrobromide
Molecular FormulaC23H26Br2N2O
Molecular Weight506.3
Topological Polar Surface Area36.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count28
Formal Charge0
Complexity510
SMILES
CN1CC[C@@]2(CC3=NC4=CC=CC=C4C=C3C[C@H]2C1)C5=CC(=CC=C5)O.Br.Br
InChI
InChI=1S/C23H24N2O.2BrH/c1-25-10-9-23(18-6-4-7-20(26)13-18)14-22-17(12-19(23)15-25)11-16-5-2-3-8-21(16)24-22;;/h2-8,11,13,19,26H,9-10,12,14-15H2,1H3;2*1H/t19-,23+;;/m0../s1
InChIKey
GWXFBFMLKRAWEU-YJKXCHRFSA-N
Chemical Structure
2D Structure
2D structure of SB 205607 dihydrobromide
CAS: 1217628-73-3
CID: 56972161
Formula: C23H26Br2N2O
MW: 506.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight506.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass506.03914
Monoisotopic Mass504.04119
Topological Polar Surface Area36.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity510
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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