TAN-67

• UNSPSC Description:

  TAN-67 (SB-205607) is a non-peptidic delta-opioid receptor agonist that exhibits significant antinociceptive activity in both diabetic and non-diabetic mice. TAN-67 demonstrates a marked and dose-dependent reduction in acetic acid-induced abdominal constrictions, with a notably stronger effect in diabetic mice compared to their non-diabetic counterparts. TAN-67's antinociceptive properties are primarily mediated through the activation of delta 1-opioid receptors, as indicated by the pronounced antagonism observed upon administration of a selective delta 1-opioid receptor antagonist.

• Target Antigen:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/tan-67.html

• Smiles:

  OC1=CC=CC([C@]23[C@@](CN(C)CC3)([H])CC4=CC5=CC=CC=C5N=C4C2)=C1

• Molecular Weight:

  344.45

• References & Citations:

  [1]Antinociceptive effects of the selective non-peptidic delta-opioid receptor agonist TAN-67 in diabetic mice

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  148545-09-9