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Pifithrin-β hydrobromide

CAT: 0931-T3637-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T3637-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
511296-88-1
Target
MDM-2/p53, Ferroptosis, p53
Related Pathways
Apoptosis
Purity
0.9974
Bioactivity
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM) .
Smiles
Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1
Molecular Formula
C16H17BrN2S
Molecular Weight
349.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Pifithrin-beta hydrobromide
CAS Number511296-88-1
PubChem CID11515812
IUPAC Name2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide
Molecular FormulaC16H17BrN2S
Molecular Weight349.3
Topological Polar Surface Area45.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity327
SMILES
CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br
InChI
InChI=1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13;/h6-10H,2-5H2,1H3;1H
InChIKey
SGNCOAOESGSEOP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pifithrin-beta hydrobromide
CAS: 511296-88-1
CID: 11515812
Formula: C16H17BrN2S
MW: 349.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight349.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass348.02958
Monoisotopic Mass348.02958
Topological Polar Surface Area45.5 Ų
Heavy Atom Count20
Formal Charge0
Complexity327
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-16702A-01Pifithrin-β (hydrobromide)
BUP05866-01Pifithrin-ß hydrobromide
256253-01Pifithrin-α hydrobromide
BUP05923-01Pifithrin-a hydrobromide
GTR19161793-01Pifithrin-β hydrobromide
HY-15484-01Pifithrin-α (hydrobromide)
ALX-270-287-M050Pifithrin-α (cyclic) . hydrobromide
A12451-25Pifithrin-?? hydrobromide 25mg
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