Pifithrin-? hydrobromide

• Target:

  MDM-2/p53|||Ferroptosis|||p53

• Related Pathways:

  Apoptosis

• Purity:

  0.9974

• Bioactivity:

  Pifithrin-? hydrobromide (Cyclic PFT-?) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 ?M) .

• Smiles:

  Br.Cc1ccc (cc1) -c1cn2c3CCCCc3sc2n1

• Molecular Formula:

  C16H17BrN2S

• Molecular Weight:

  349.29

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  511296-88-1