Pifithrin-β hydrobromide

CAT: 0931-T3637-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0931-T3637-01Size:2 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

511296-88-1

Target

MDM-2/p53, Ferroptosis, p53

Related Pathways

Apoptosis

Purity

0.9974

Bioactivity

Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM) .

Smiles

Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1

Molecular Formula

C16H17BrN2S

Molecular Weight

349.29

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-16702A-01	Pifithrin-β (hydrobromide)
BUP05866-01	Pifithrin-ß hydrobromide
GTR19161793-01	Pifithrin-β hydrobromide
256253-01	Pifithrin-α hydrobromide
BUP05923-01	Pifithrin-a hydrobromide
HY-15484-01	Pifithrin-α (hydrobromide)
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Pifithrin-β hydrobromide

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