Pifithrin-? hydrobromide

CAT: 0931-MF-0018367-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0018367-01Size:2 mg
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CAS Number
511296-88-1
Target
MDM-2/p53|||Ferroptosis|||p53
Related Pathways
Apoptosis
Purity
0.9974
Bioactivity
Pifithrin-? hydrobromide (Cyclic PFT-?) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 ?M) .
Smiles
Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1
Molecular Formula
C16H17BrN2S
Molecular Weight
349.29
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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