CAY10535

• CAS Number :

  945716-28-9

• Target :

  Others|||Prostaglandin Receptor

• Related Pathways :

  Others|||Immunology/Inflammation|||GPCR/G Protein

• Bioactivity :

  TP? and TP? are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2) . Although their distinct physiological functions have not been fully elucidated, TP? is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TP? appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TP? (IC50 = 99 nM) relative to TP? (IC50 = 1,970 nM) in the inhibition of U46619-mediated Ca2+ mobilization. This compound exhibits relatively poor activity on platelets (IC50 = 985 nM) when inhibiting U-46619-induced platelet aggregation.

• Smiles :

  O(C1=C(S(NC(NC(C)(C)C)=O)(=O)=O)C=C(N(=O)=O)C=C1)C2=CC(OC)=CC=C2

• Molecular Formula :

  C18H21N3O7S

• Molecular Weight :

  423.44

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C