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CAY10512

CAT: 0804-HY-120269-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120269-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAY10512 is a NF-κB inhibitor. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid. CAY10512 significantly reduces the release of pro-inflammatory cytokines (such as TNF-α, MCP-1, IL-8, IL-6) . CAY10512 can be used for researchs on neuroinflammation, islet transplantation and microRNA regulation[1][2][3].
CAS Number
139141-12-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Interleukin Related; NF-κB; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cay10512.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
COC(C=C1)=CC=C1/C=C/C2=C(C=CC=C2)F
Molecular Formula
C15H13FO
Molecular Weight
228.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Alexandrov P N, et al. microRNA (miRNA) speciation in Alzheimer’s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF) [J]. International journal of biochemistry and molecular biology, 2012, 3 (4) : 365.|[2]Kanak MA, et al. Alleviation of instant blood-mediated inflammatory reaction in autologous conditions through treatment of human islets with NF-κB inhibitors. Transplantation. 2014 Sep 15;98 (5) :578-84.|[3]Chantong B, et al. Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells. J Neuroinflammation. 2012 Nov 28;9:260.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; IL-8; NF-κB

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