α7 nAchR-JAK2-STAT3 agonist 1

α7 nAchR-JAK2-STAT3 agonist 1

• CAS Number: 2108714-20-9
• UNSPSC Description: α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].
• Target Antigen: JAK; nAChR; NO Synthase; STAT
• Type: Reference compound
• Related Pathways: Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Membrane Transporter/Ion Channel;Neuronal Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/α7-nachr-jak2-stat3-agonist-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O[C@@H](CCCCC1=CC=CC=C1)CCC2=CC=C(OC(C)=O)C(OC(C)=O)=C2)C
• Molecular Weight: 426.50
• References & Citations: [1]Lin Y, et al. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorg Med Chem. 2022;66:116811.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported