(±) 11 (12) -EET

• Target:

  NOD-like Receptor (NLR) |||Others

• Related Pathways:

  Others|||Immunology/Inflammation

• Bioactivity:

  (±) 11 (12) -EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3] A higher proportion of 11 (R),12 (S) -EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24, while CYP2B2 produces a higher proportion of 11 (S),12 (R) -EET.[3] 11 (12) -EET has been shown, along with 8 (9) -EET, to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells.[4] It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct at a concentration of 100 nM.[5] 11 (12) -EET (50 ?g/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation.[6] It also has anti-inflammatory, angiogenic, and cardioprotective properties.[7]

• Smiles:

  CCCCC\C=C/C[C@H]1O[C@H]1C\C=C/C\C=C/CCCC (O) =O

• Molecular Formula:

  C20H32O3

• Molecular Weight:

  320.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  123931-40-8