(±) 11 (12) -EET

CAT: 0931-T35494Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T35494Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
123931-40-8
Target
NOD-like Receptor (NLR) |||Others
Related Pathways
Others|||Immunology/Inflammation
Bioactivity
(±) 11 (12) -EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3] A higher proportion of 11 (R),12 (S) -EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24, while CYP2B2 produces a higher proportion of 11 (S),12 (R) -EET.[3] 11 (12) -EET has been shown, along with 8 (9) -EET, to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells.[4] It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct at a concentration of 100 nM.[5] 11 (12) -EET (50 ?g/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation.[6] It also has anti-inflammatory, angiogenic, and cardioprotective properties.[7]
Smiles
CCCCC\C=C/C[C@H]1O[C@H]1C\C=C/C\C=C/CCCC(O)=O
Molecular Formula
C20H32O3
Molecular Weight
320.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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