(±) 11 (12) -EET-d11

• Description:

  (±) 11 (12) -EET-d11 is the deuterium labeled (±) 11 (12) -EET. (±) 11 (12) -EET is a NLRP3 inflammasome inhibitor. (±) 11 (12) -EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].

• Product Name Alternative:

  (±) 11,12-EET-d11

• UNSPSC:

  12352005

• Target:

  NOD-like Receptor (NLR)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Concentration:

  301.63 μM * 100 μL in Ethanol

• Purity:

  98.0

• Smiles:

  [2H]C ([2H]) (C ([2H]) (/C=C\C[C@@H]1[C@H] (C/C=C\C/C=C\CCCC (O) =O) O1) [2H]) C ([2H]) (C ([2H]) (C ([2H]) ([2H]) [2H]) [2H]) [2H]

• Molecular Formula:

  C20H21D11O3

• Molecular Weight:

  331.53

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2] Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235 (12) :9910-9921.|[3]Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104 (3) :916-922.|[4]Oliw EH, et al. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem. 1982;257 (7) :3771-3781.|[5]Capdevila JH, et al. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41 (2) :163-181.|[6]Wang Z, et al. Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. Am J Physiol Renal Physiol. 2008;294 (6) :F1441-F1447.|[7]Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50 Suppl (Suppl) :S52-S56.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  2699607-19-5