(±) 14 (15) -EET

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  (±) 14 (15) -EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1], [2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 ?M.[3] (±) 14 (15) -EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM) .[4] It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion.[5]

• Smiles:

  CCCCCC1OC1C\C=C/C\C=C/C\C=C/CCCC(O)=O

• Molecular Formula:

  C20H32O3

• Molecular Weight:

  320.473

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  197508-62-6