(±) 14 (15) -EET

CAT: 0931-MF-0000749Size: 100 µgDry Ice: NoHazardous: No
CAT#:0931-MF-0000749Size:100 µg
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CAS Number
197508-62-6
Target
Others
Related Pathways
Others
Bioactivity
(±) 14 (15) -EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1], [2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 ?M.[3] (±) 14 (15) -EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM) .[4] It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion.[5]
Smiles
CCCCCC1OC1C\C=C/C\C=C/C\C=C/CCCC(O)=O
Molecular Formula
C20H32O3
Molecular Weight
320.473
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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