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(±) 11 (12) -EET methyl ester-d11

CAT: 0804-HY-139938S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139938S-01Size:5 mg
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Description
(±) 11 (12) -EET-d11 methyl ester (11,12-EET methyl ester-d11) is the deuterium labeled (±) 11 (12) -EET methyl ester. (±) 11 (12) -EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±) 11 (12) -EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±) 11 (12) -EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±) 11 (12) -EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis[1][2].
Product Name Alternative
11,12-EET methyl ester-d11; (±) 11,12-EpETrE methyl ester-d11
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])(C([2H])(/C=C\C[C@@H]1[C@H](C/C=C\C/C=C\CCCC(OC)=O)O1)[2H])C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H]
Molecular Formula
C21H23D11O3
Molecular Weight
345.56
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Lahvic JL, et al. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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