(±) 5 (6) -EET

CAT: 0931-MF-0035688-01Size: 25 µgDry Ice: NoHazardous: No
CAT#:0931-MF-0035688-01Size:25 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
87173-80-6
Target
Calcium Channel|||Others|||Adrenergic Receptor
Related Pathways
Metabolism|||Others|||Neuroscience|||GPCR/G Protein|||Membrane transporter/Ion channel
Bioactivity
5 (6) -EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5 (6) -EET degrades into 5,6-DiHET and 5 (6) -?-lactone, which can be converted to 5 (6) -DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5 (6) -EET has been implicated in the mobilization of calcium and hormone secretion. 5 (6) -EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 ?M), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 ?M. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 ?M. (±) 5 (6) -EET is provided as a mixture of the free acid and lactone.
Smiles
CCCCC\C=C/C\C=C/C\C=C/C[C@H]1O[C@H]1CCCC(O)=O
Molecular Formula
C20H32O3
Molecular Weight
320.473
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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