(±) 5 (6) -EET

• Target :

  Calcium Channel|||Others|||Adrenergic Receptor

• Related Pathways :

  Metabolism|||Others|||Neuroscience|||GPCR/G Protein|||Membrane transporter/Ion channel

• Bioactivity :

  5 (6) -EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5 (6) -EET degrades into 5,6-DiHET and 5 (6) -?-lactone, which can be converted to 5 (6) -DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5 (6) -EET has been implicated in the mobilization of calcium and hormone secretion. 5 (6) -EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 ?M), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 ?M. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 ?M. (±) 5 (6) -EET is provided as a mixture of the free acid and lactone.

• Smiles :

  CCCCC\C=C/C\C=C/C\C=C/C[C@H]1O[C@H]1CCCC(O)=O

• Molecular Formula :

  C20H32O3

• Molecular Weight :

  320.473

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  87173-80-6