IWP-051

• Target:

  Others|||Guanylate cyclase

• Related Pathways:

  Others|||GPCR/G Protein

• Bioactivity:

  IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM) . IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.

• Smiles:

  C(N1C(=CC(=N1)C=2NC(=O)C(F)=CN2)C=3C=CON3)C4=C(F)C=CC=C4

• Molecular Formula:

  C17H11F2N5O2

• Molecular Weight:

  355.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1354041-91-0