IWP-051

CAT: 0804-HY-117443Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117443Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IWP-051 is an agonist for soluble guanylate cyclase with an EC50 of 290 nM. IWP-051 stimulates the generation of cGMP, and exhibits the synergistic effect with NO. IWP-051 exhibits good pharmacokinetic characteristics in rats[1].
CAS Number
[1354041-91-0]
UNSPSC
12352005
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/iwp-051.html
Smiles
O=C1NC(C2=NN(CC3=CC=CC=C3F)C(C4=NOC=C4)=C2)=NC=C1F
Molecular Formula
C17H11F2N5O2
Molecular Weight
355.30
References & Citations
[1]Nakai T, et al., Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans. ACS Med Chem Lett. 2016 Feb 24;7 (5) :465-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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