IWP-051

• Description :

  IWP-051 is an agonist for soluble guanylate cyclase with an EC50 of 290 nM. IWP-051 stimulates the generation of cGMP, and exhibits the synergistic effect with NO. IWP-051 exhibits good pharmacokinetic characteristics in rats[1].

• UNSPSC :

  12352005

• Target :

  Guanylate Cyclase

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/iwp-051.html

• Smiles :

  O=C1NC(C2=NN(CC3=CC=CC=C3F)C(C4=NOC=C4)=C2)=NC=C1F

• Molecular Formula :

  C17H11F2N5O2

• Molecular Weight :

  355.30

• References & Citations :

  [1]Nakai T, et al., Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans. ACS Med Chem Lett. 2016 Feb 24;7 (5) :465-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1354041-91-0]