IWP-051

• UNSPSC Description:

  IWP-051 is an agonist for soluble guanylate cyclase with an EC50 of 290 nM. IWP-051 stimulates the generation of cGMP, and exhibits the synergistic effect with NO. IWP-051 exhibits good pharmacokinetic characteristics in rats[1].

• Target Antigen:

  Guanylate Cyclase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/iwp-051.html

• Smiles:

  O=C1NC(C2=NN(CC3=CC=CC=C3F)C(C4=NOC=C4)=C2)=NC=C1F

• Molecular Weight:

  355.30

• References & Citations:

  [1]Nakai T, et al., Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans. ACS Med Chem Lett. 2016 Feb 24;7(5):465-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1354041-91-0