TP-051

• Description:

  TP-051, a chemical probe, is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes[1].

• UNSPSC:

  12352005

• Target:

  Free Fatty Acid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/tp-051.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (CCC1=CC=C (C=C1F) OCC2=CC=CC (C3=C (C) C=C (C=C3C) OC4CCS (=O) (CC4) =O) =C2) O

• Molecular Formula:

  C29H31FO6S

• Molecular Weight:

  526.62

• References & Citations:

  [1]Mikami S, et al. Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem. 2012 Apr 26;55 (8) :3756-76.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  858097-86-6