CHIR-124

• Target:

  Src|||Chk|||FLT|||Apoptosis|||GSK-3|||PDGFR

• Related Pathways:

  Apoptosis|||PI3K/Akt/mTOR signaling|||Cell Cycle/Checkpoint|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Stem Cells

• Purity:

  0.9835

• Bioactivity:

  CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM) . It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.

• Smiles:

  Clc1ccc2[nH]c (=O) c (-c3nc4ccccc4[nH]3) c (N[C@@H]3CN4CCC3CC4) c2c1

• Molecular Formula:

  C23H22ClN5O

• Molecular Weight:

  419.91

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  405168-58-3