CHIR-124

• Target :

  Src|||Chk|||FLT|||Apoptosis|||GSK-3|||PDGFR

• Related Pathways :

  Apoptosis|||PI3K/Akt/mTOR signaling|||Cell Cycle/Checkpoint|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Stem Cells

• Purity :

  0.9835

• Bioactivity :

  CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM) . It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.

• Smiles :

  Clc1ccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N[C@@H]3CN4CCC3CC4)c2c1

• Molecular Formula :

  C23H22ClN5O

• Molecular Weight :

  419.91

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  405168-58-3