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ST-CY14

CAT: 0931-TP3109-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3109-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
NR4A, Mitochondrial Metabolism
Related Pathways
Endocrinology/Hormones, Metabolism
Bioactivity
ST-CY14 is an inhibitor of the Nur77-PPARγ interaction with an EC50 of 3.15 μM. It binds to Nur77 (Kd=32 nM) to prevent its ubiquitination and degradation by PPARγ, reducing fatty acid uptake and mitochondrial respiration, and inhibiting the transcription of CD36 and FABP4. ST-CY14 suppresses proliferation and migration of MCF7 and MDA-MB-231 cancer cells and impedes tumor growth and bone metastasis in mouse models.
Molecular Formula
C139H237N57O31S2
Molecular Weight
3266.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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