ST-CY14

• Target:

  NR4A|||Mitochondrial Metabolism

• Related Pathways:

  Endocrinology/Hormones|||Metabolism

• Bioactivity:

  ST-CY14 is an inhibitor of the Nur77-PPAR? interaction with an EC50 of 3.15 ?M. It binds to Nur77 (Kd=32 nM) to prevent its ubiquitination and degradation by PPAR?, reducing fatty acid uptake and mitochondrial respiration, and inhibiting the transcription of CD36 and FABP4. ST-CY14 suppresses proliferation and migration of MCF7 and MDA-MB-231 cancer cells and impedes tumor growth and bone metastasis in mouse models.

• Molecular Formula:

  C139H237N57O31S2

• Molecular Weight:

  3266.86

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C