ST-899

• Target :

  TNF|||PAFR

• Related Pathways :

  Apoptosis|||GPCR/G Protein

• Bioactivity :

  ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS) . The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.

• Smiles :

  C(\COC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O)=C\1/C=2C(C(=O)O1)=CC=C(Cl)C2.[Br-]

• Molecular Formula :

  C22H29BrClNO6

• Molecular Weight :

  518.83

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  143484-41-7