ST-899

CAT: 0931-MF-0118219-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118219-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
143484-41-7
Target
TNF|||PAFR
Related Pathways
Apoptosis|||GPCR/G Protein
Bioactivity
ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS) . The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.
Smiles
C(\COC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O)=C\1/C=2C(C(=O)O1)=CC=C(Cl)C2.[Br-]
Molecular Formula
C22H29BrClNO6
Molecular Weight
518.83
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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