AM-0687

CAT: 0931-T26607-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T26607-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1259522-94-5

Target

Others, PI3K

Related Pathways

Others, PI3K/Akt/mTOR signaling

Bioactivity

AM-0687 is a potent and selective PI3Kδ inhibitor. AM-0687 has Cellular potency: pAKT IC50 = 0.7 nM; HWB, u (pAKT) IC 50 = 4.6 nM. Rat KLH: IgG ED50 -= 0.026 mg/kg; IgM ED50 = 0.016 mg/kg. Rat PK Clu = 2.3 L/hr/kg.

Smiles

C(NC)(=O)C1=C(C([C@@H](NC=2C(C#N)=C(N)N=CN2)C)=NC3=C1C=C(F)C=C3)C4=CC=CC=N4

Molecular Formula

C23H19FN8O

Molecular Weight

442.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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