AM-0687

• Target:

  Others|||PI3K

• Related Pathways:

  Others|||PI3K/Akt/mTOR signaling

• Bioactivity:

  AM-0687 is a potent and selective PI3K? inhibitor. AM-0687 has Cellular potency: pAKT IC50 = 0.7 nM; HWB, u (pAKT) IC 50 = 4.6 nM. Rat KLH: IgG ED50 -= 0.026 mg/kg; IgM ED50 = 0.016 mg/kg. Rat PK Clu = 2.3 L/hr/kg.

• Smiles:

  C (NC) (=O) C1=C (C ([C@@H] (NC=2C (C#N) =C (N) N=CN2) C) =NC3=C1C=C (F) C=C3) C4=CC=CC=N4

• Molecular Formula:

  C23H19FN8O

• Molecular Weight:

  442.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1259522-94-5