PX-12

• Target :

  Others|||Apoptosis|||Thioredoxin

• Related Pathways :

  Metabolism|||Others|||Apoptosis

• Purity :

  0.996

• Bioactivity :

  PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1? and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival.

• Smiles :

  CCC(C)SSc1ncc[nH]1

• Molecular Formula :

  C7H12N2S2

• Molecular Weight :

  188.31

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  141400-58-0