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CHK1-IN-12

CAT: 0931-T207228-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207228-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Chk
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.
Molecular Formula
C19H19N7O2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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