KH-CB19

CAT: 0804-HY-12828-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-12828-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM) . KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM) [1][2].

CAS Number

1354037-26-5

UNSPSC

12352005

Hazard Statement

H302

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/KH-CB19.html

Purity

99.31

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CCOC(C1=C(C2=C(C(Cl)=C(C=C2)Cl)N1C)/C(C#N)=C\N)=O

Molecular Formula

C15H13Cl2N3O2

Molecular Weight

338.19

Precautions

H302

References & Citations

[1]Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18 (1) :67-76.|[2]Artarini A, et al. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Res. 2019 Aug;168:187-196.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CLK

Related Products

Catalog	Name
HY-134601-01	KH-3
HY-150503	KH-259
HY-12828A-01	KH-CB20
HY-148602-01	KH-4-43
HY-126160	CB10-277
HY-172409	CB1R antagonist 2
HY-150067-01	CB1R antagonist 1
HY-168997	CB1R agonist 1
HY-174838	CB1-IN-3
HY-12790-01	CB1-IN-1

Alternative Products

Catalog	Name
B5548-5.1	KH CB19
EEC03726-01	KH-CB19
217260-01	Cdc2-Like Kinase Inhibitor IV (KH-CB19)
B7510-50	KH 7
BA4888-10	KH-3
BA3839-1	KH-CB20
GTR19242131-01	KH-176M
T61073-01	KH-259
T32391	KH 1049
M13449-01	KH 176

KH-CB19

Related Products

Alternative Products

Popular Products