KH-259

• Description:

  KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research[1].

• UNSPSC:

  12352005

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/kh-259.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(N1CCN(CC2=CC=C(C(NO)=O)C=C2)CC1)C3=CC=CC=C3

• Molecular Formula:

  C20H25N3O2

• Molecular Weight:

  339.43

• References & Citations:

  [1]Kosuke Hashimoto, et al. Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors. ACS Med. Chem. Lett. 2022 June 28.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC1; HDAC4; HDAC6

• CAS Number:

  [3023019-93-1]