KH-3

• Description :

  KH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HuR

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/kh-3.html

• Purity :

  98.20

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NO)/C=C/C1=CC2=CC(NS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)=CC=C2S1

• Molecular Formula :

  C21H22N2O4S2

• Molecular Weight :

  430.54

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Wu X, et, al. Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis. Commun Biol. 2020 Apr 24;3 (1) :193.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1215115-03-9]