C-021

CAT: 0931-T21870-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T21870-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
864289-85-0
Target
CCR
Related Pathways
GPCR/G Protein|||Immunology/Inflammation|||Microbiology/Virology
Purity
>99.99%
Bioactivity
C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTP?S from binding to the receptor (IC50: 18 nM) .
Smiles
N(C=1C2=C(N=C(N1)N3CCC(CC3)N4CCCCC4)C=C(OC)C(OC)=C2)C5CCCCCC5
Molecular Formula
C27H41N5O2
Molecular Weight
467.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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