C-021

• Target:

  CCR

• Related Pathways:

  GPCR/G Protein|||Immunology/Inflammation|||Microbiology/Virology

• Purity:

  >99.99%

• Bioactivity:

  C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTP?S from binding to the receptor (IC50: 18 nM) .

• Smiles:

  N (C=1C2=C (N=C (N1) N3CCC (CC3) N4CCCCC4) C=C (OC) C (OC) =C2) C5CCCCCC5

• Molecular Formula:

  C27H41N5O2

• Molecular Weight:

  467.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  864289-85-0