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TX1-85-1

CAT: 0931-T17182-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T17182-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1603845-32-4
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling
Purity
0.9812
Bioactivity
TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM) . TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
Smiles
CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12
Molecular Formula
C32H36N8O3
Molecular Weight
580.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C