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TX1-85-1 (Standard)

CAT: 0804-HY-100848RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100848RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TX1-85-1 (Standard) is the analytical standard of TX1-85-1. This product is intended for research and analytical applications. TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1].
CAS Number
1603845-32-4
Target
EGFR; Reference Standards
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O
Molecular Formula
C32H36N8O3
Molecular Weight
580.68
References & Citations
[1]Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10 (12) :1006-12.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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