GNE-049

• Target :

  Epigenetic Reader Domain|||Histone Acetyltransferase

• Related Pathways :

  Chromatin/Epigenetic

• Purity :

  0.9867

• Bioactivity :

  GNE-049 is a highly selective and potent inhibitor designed to target the CREB-binding protein (CBP) with high affinity, exhibiting an IC50 of 1.1 nM for the suppression of BRET and BRD4 activity, which consequently blocks prostate cancer cell proliferation in both in vitro and in vivo models.

• Smiles :

  O=C(N1CC=2C(=NN(C2CC1)C3CCOCC3)N4C=5C=C(C(=CC5CCC4)C=6C=NN(C6)C)C(F)F)C

• Molecular Formula :

  C27H32F2N6O2

• Molecular Weight :

  510.58

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1936421-41-8