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SPDP (Standard)

CAT: 0804-HY-100216RSize: 1 EachDry Ice: NoHazardous: No
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Description
SPDP (Standard) is the analytical standard of SPDP. This product is intended for research and analytical applications. SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[2].
CAS Number
68181-17-9
Target
ADC Linker; Reference Standards
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Field of Research
Cancer
Smiles
O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Molecular Formula
C12H12N2O4S2
Molecular Weight
312.37
References & Citations
[1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104 (11) :4612-7.|[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184 (12) :6695-708.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

N-Succinimidyl 3-(2-pyridyldithio)propionate

heterobifunctional reagent

CAS Number68181-17-9
PubChem CID100682
IUPAC Name(2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
Molecular FormulaC12H12N2O4S2
Molecular Weight312.4
XLogP0.7
Topological Polar Surface Area127
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count20
Formal Charge0
Complexity376
SMILES
C1CC(=O)N(C1=O)OC(=O)CCSSC2=CC=CC=N2
InChI
InChI=1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
InChIKey
JWDFQMWEFLOOED-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Succinimidyl 3-(2-pyridyldithio)propionate
CAS: 68181-17-9
CID: 100682
Formula: C12H12N2O4S2
MW: 312.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight312.4
XLogP30.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass312.02384922
Monoisotopic Mass312.02384922
Topological Polar Surface Area127 Ų
Heavy Atom Count20
Formal Charge0
Complexity376
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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