TD-428

• Target:

  PROTACs|||Epigenetic Reader Domain

• Related Pathways:

  Chromatin/Epigenetic|||PROTAC

• Bioactivity:

  TD-428 is a highly specific degrader of BRD4 (DC50 of 0.32 nM) . TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor) . TD-428 efficiently induce BET protein degradation.

• Smiles:

  O=C (NC1=CC (OCCOCCOCCNC2=C3C (N=NN (C (CC4) C (NC4=O) =O) C3=O) =CC=C2) =CC=C1) C[C@H]5C6=NN=C (C) N6C7=C (C (C) =C (C) S7) C (C8=CC=C (Cl) C=C8) =N5

• Molecular Formula:

  C43H43ClN10O7S

• Molecular Weight:

  879.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C