TD-428

• Target:

  PROTACs|||Epigenetic Reader Domain

• Related Pathways:

  Chromatin/Epigenetic|||PROTAC

• Bioactivity:

  TD-428 is a highly specific degrader of BRD4 (DC50 of 0.32 nM) . TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor) . TD-428 efficiently induce BET protein degradation.

• Smiles:

  O=C(NC1=CC(OCCOCCOCCNC2=C3C(N=NN(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)=CC=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5

• Molecular Formula:

  C43H43ClN10O7S

• Molecular Weight:

  879.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C