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WHN-11

CAT: 0804-HY-175221Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175221Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WHN-11 is an amino-Artemisinin derivative with anti-cancer activity against various cancer cell lines. WHN-11 deprives the cell of ATP, activates autophagy, and causes subsequent cell death by apoptosis. WHN-11 alters cellular protein homeostasis pathways to induce mitochondrial fission and dysfunction. WHN-11's anti-cancer activity is independent of substantive ROS production. WHN-11 can be used for the study of triple-negative breast cancer (TNBC).
UNSPSC
12352005
Target
Apoptosis; Autophagy
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@H]1N5CCN(CC5)C(NC6=CC=C(C=C6)C(F)(F)F)=O
Molecular Formula
C27H36F3N3O5
Molecular Weight
539.59
References & Citations
[1]Kajewole D, et al. The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells. Sci Rep. 2025 Jul 1;15 (1) :21604.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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