ROCK-IN-11

• Description:

  ROCK-IN-11 (example 94) is a potent inhibitor of ROCK1 and ROCK2, with the IC50 of ≤ 5μM. ROCK-IN-11 plays an important role in cancer research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  ROCK

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  COC1=C(C(=CC(=C1)NC(=O)C2=C(C3=C(N=C(C=C3)C4=CC=NC=C4)S2)N)OC)OC

• Molecular Formula:

  C22H20N4O4S

• Molecular Weight:

  436.48

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Mehmet Kahraman, et al. Benzothiophene derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as inhibitors of Rho kinase. World Intellectual Property Organization, WO2008011560 A2 2008-01-24

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [445267-51-6]