D-Psicose-d

• Description :

  D-Psicose-d is the deuterium labeled D-Psicose (HY-N9914) . D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease[1][2][3][4][5].

• Product Name Alternative :

  D-Allulose-d

• UNSPSC :

  12352211

• Target :

  Isotope-Labeled Compounds; NF-κB; p38 MAPK

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  MAPK/ERK Pathway; NF-κB; Others

• Field of Research :

  Metabolic Disease

• Purity :

  99.9

• Solubility :

  10 mM in DMSO

• Smiles :

  OCC([C@]([C@@H]([C@@H](CO)O)O)([2H])O)=O

• Molecular Formula :

  C6H11DO6

• Molecular Weight :

  181.16

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Murao K, et al. D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs. Life Sci. 2007 Jul 26;81 (7) :592-9.|[3]Hossain A, et al. Rare sugar D-psicose protects pancreas β-islets and thus improves insulin resistance in OLETF rats. Biochem Biophys Res Commun. 2012 Sep 7;425 (4) :717-23.|[4]Baek SH, et al. D-psicose, a sweet monosaccharide, ameliorate hyperglycemia, and dyslipidemia in C57BL/6J db/db mice. J Food Sci. 2010 Mar;75 (2) :H49-53.|[5]Tan J, et al. D-Psicose mitigates NAFLD mice induced by a high-fat diet by reducing lipid accumulation, inflammation, and oxidative stress. Front Nutr. 2025 May 27;12:1574151. |[6]Zeng Y, et al. Dietary D-psicose, a rare sugar, shows no modifying effects in a medium-term liver carcinogenesis bioassay in F344 male rats. Journal of toxicologic pathology, 2005, 18 (2) : 85-88.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [53685-24-8]