Thalidomide (Standard)

CAT: 0804-HY-14658R-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14658R-01Size:10 mg
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Description
Thalidomide (Standard) is the analytical standard of Thalidomide. This product is intended for research and analytical applications. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
CAS Number
[50-35-1]
UNSPSC
12352005
Hazard Statement
H301, H312, H360
Target
Apoptosis; Autophagy; Ligands for E3 Ligase; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Others; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/thalidomide-standard.html
Purity
99.96
Smiles
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC=C31)=O
Molecular Formula
C13H10N2O4
Molecular Weight
258.23
Precautions
H301, H312, H360
References & Citations
[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.|[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.|[3]Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Isoform
Cereblon

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