Thalidomide (Standard)

• Description:

  Thalidomide (Standard) is the analytical standard of Thalidomide. This product is intended for research and analytical applications. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H312, H360

• Target:

  Apoptosis; Autophagy; Ligands for E3 Ligase; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Apoptosis; Autophagy; Others; PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-standard.html

• Purity:

  99.96

• Smiles:

  O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC=C31)=O

• Molecular Formula:

  C13H10N2O4

• Molecular Weight:

  258.23

• Precautions:

  H301, H312, H360

• References & Citations:

  [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.|[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.|[3]Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• Isoform:

  Cereblon

• CAS Number:

  50-35-1