Oligomycin E

• Description:

  Oligomycin E is a antitumor antibiotic that can be isolated from Streptomyces. Oligomycin E has significant antifungal activity, showing minimal inhibitory concentrations (MICs) values between 2 and 75μg/mL. Oligomycin E has strong antitumor activity against HeLa cells, with an IC50 of 0.014 μg/mL[1].

• UNSPSC:

  12352005

• Target:

  Antibiotic; Fungal

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/oligomycin-e.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@@H]1C)=O)O[C@@]([C@@H]2C)([H])[C@@](C)(O)[C@@]3(C(C[C@H](C)[C@H](C[C@H](O)C)O3)=O)O[C@@]2([H])CC[C@@H](CC)/C=C/C=C/C[C@@H](C)[C@H](O)[C@@](C)(O)C1=O

• Molecular Formula:

  C45H72O13

• Molecular Weight:

  821.05

• References & Citations:

  [1]Kobayashi K, et al. Oligomycin E, a new antitumor antibiotic produced by Streptomyces sp. MCI-2225. J Antibiot (Tokyo) . 1987 Jul;40 (7) :1053-7.|[2]Khebizi N, et al. Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil. J Mycol Med. 2018 Mar;28 (1) :150-160.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [110231-34-0]