Oligomycin

• UNSPSC Description:

  Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells[1][2][3][4].

• Target Antigen:

  Antibiotic; ATP Synthase; Fungal; Oxidative Phosphorylation

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/oligomycin.html

• Purity:

  99.0

• Solubility:

  DMSO : 20 mg/mL (ultrasonic;warming)|Ethanol : 30 mg/mL (ultrasonic;warming)

• Smiles:

  [Oligomycin]

• References & Citations:

  [1]Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796.|[2]SMITH RM, et al. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970.|[3]López de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976.|[4]Gong Y, et al. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. Am J Physiol Cell Physiol. 2005;288(5):C1023-C1029.|[5]Shchepina LA, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. 2002;21(53):8149-8157.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1404-19-9