(E, E) -GLL398

• Description :

  (E, E) -GLL398 is a selective estrogen receptor degrader with potent binding activity to ERα (IC50 = 1.14 nM) . (E, E) -GLL398 can effectively degrade ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM) . The introduced boronic acid group of (E, E) -GLL398 gives it superior oral bioavailability, with an AUC of 36.9 μg·h/mL in rats, which is significantly higher than that of GW7604[1].

• UNSPSC :

  12352005

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/e-e-gll398.html

• Smiles :

  O=C(/C=C/C1=CC=C(C=C1)/C(C2=CC=C(C=C2)B(O)O)=C(CC)/C3=CC=CC=C3)O

• Molecular Formula :

  C25H23BO4

• Molecular Weight :

  398.26

• References & Citations :

  [1]Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2077980-83-5]