SC-75416

CAT: 0804-HY-19500-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19500-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SC-75416 is a selective cyclooxygenase-2 inhibitor. Its pharmacokinetic/pharmacodynamic (PK/PD) model was used for development and clinical trial simulation to design a study protocol to verify its analgesic effect in a post-oral surgery pain model. The simulation results showed that 360 mg of SC-75416 may provide better pain relief than 400 mg of ibuprofen. The actual clinical trial results confirmed this hypothesis, and 360 mg of SC-75416 was indeed superior to 400 mg of ibuprofen in pain relief. The PK/PD model of SC-75416 showed good predictive performance and successfully predicted its clinical effect. These research results show that SC-75416, as a new selective COX-2 inhibitor, has potential clinical application value in the management of post-oral surgery pain.
CAS Number
[215122-74-0]
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sc-75416.html
Smiles
O=C(C1=CC2=CC(Cl)=C(C(C)(C)C)C=C2O[C@@H]1C(F)(F)F)O
Molecular Formula
C15H14ClF3O3
Molecular Weight
334.72
References & Citations
[1]Modeling and Simulation to Support Dose Selection and Clinical Development of SC-75416, a Selective COX-2 Inhibitor for the Treatment of Acute and Chronic Pain
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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