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PARP10/15-IN-1

CAT: 0804-HY-143398-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-143398-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of PARP10 and PARP15, with IC50s of 160 nM and 370 nM, respectively. PARP10/15-IN-1 can be used for cancer[1].
CAS Number
2892065-01-7
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp10-15-in-1.html
Concentration
10mM
Purity
95.04
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NNC(C2=C1C=CC(OCC3=CSC=C3)=C2)=O
Molecular Formula
C13H10N2O3S
Molecular Weight
274.30
References & Citations
[1]Nizi MG, et, al. Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem. 2022 Apr 19;237:114362.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP10; PARP15

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