PARP1-IN-15

PARP1-IN-15

• UNSPSC Description: PARP1-IN-15 (Compound 6) is a PARP1 inhibitor. PARP1-IN-15 inhibits tankyrase (TNKS) and facilitates DNA double-strand breaks damage. PARP1-IN-15 induces tumor cell apoptosis. PARP1-IN-15 has anti-cancer activity in triple-negative breast cancer (TNBC) cells and TNBC patient-derived organoids. PARP1-IN-15 can be used for research of TNBC with or without BRCA1 mutations[1].
• Target Antigen: Apoptosis; PARP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp1-in-15.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC(/C=C/C2=CC=C(O)C=C2)=NC3=CC=CC=C31
• Molecular Weight: 264.28
• References & Citations: [1]Gong R, et al. Identification and evaluation of a novel PARP1 inhibitor for the treatment of triple-negative breast cancer. Chem Biol Interact. 2023 Sep 1;382:110567.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported