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PARP10-IN-2

CAT: 0804-HY-148753-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148753-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].
CAS Number
1042780-52-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp10-in-2.html
Purity
98.02
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C=C1)OC2=CC=C(C(N)=O)C=C2
Molecular Formula
C14H10N2O2
Molecular Weight
238.24
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10 (10) :939-948.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP10; PARP12; PARP14; PARP15; PARP16; PARP2; PARP3; PARP4; TNKS1/PARP5A; TNKS2/PARP5B

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