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PARP10-IN-3

CAT: 0804-HY-148754-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148754-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC50s of 1.7 μM for human PARP2 and human PARP15, respectively[1].
CAS Number
2225800-19-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp10-in-3.html
Purity
98.72
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C=C1)OC2=CC=CC(C(N)=O)=C2)N
Molecular Formula
C14H12N2O3
Molecular Weight
256.26
Precautions
H302, H315, H319
References & Citations
[1]Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10 (10) :939-948.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP10; PARP12; PARP14; PARP15; PARP16; PARP2; PARP3; PARP4; TNKS1/PARP5A; TNKS2/PARP5B

Chemical Information

3-(4-Carbamoylphenoxy)benzamide
CAS Number2225800-19-9
PubChem CID69845715
IUPAC Name3-(4-carbamoylphenoxy)benzamide
Molecular FormulaC14H12N2O3
Molecular Weight256.26
XLogP2.1
Topological Polar Surface Area95.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count19
Formal Charge0
Complexity338
SMILES
C1=CC(=CC(=C1)OC2=CC=C(C=C2)C(=O)N)C(=O)N
InChI
InChI=1S/C14H12N2O3/c15-13(17)9-4-6-11(7-5-9)19-12-3-1-2-10(8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18)
InChIKey
PMOXYDXLQIUWHL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Carbamoylphenoxy)benzamide
CAS: 2225800-19-9
CID: 69845715
Formula: C14H12N2O3
MW: 256.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight256.26
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass256.08479225
Monoisotopic Mass256.08479225
Topological Polar Surface Area95.4 Ų
Heavy Atom Count19
Formal Charge0
Complexity338
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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