ER-Tracker Red

• Description:

  ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K+ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation. Ex/Em=587/615 nm[1].

• UNSPSC:

  12171500

• Target:

  Fluorescent Dye

• Type:

  Dye Reagents

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/er-tracker-red.html

• Purity:

  98.08

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)

• Smiles:

  O=C(C(C=C(Cl)C=C1NC(COC2=CC=C(C3=[N]4C(C=C3)=CC5=CC=C(C6=CC=CS6)[N-]5[B+3]4([F-])[F-])C=C2)=O)=C1OC)NCCC(C=C7)=CC=C7S(NC(NC8CCCCC8)=O)(=O)=O

• Molecular Formula:

  C44H42BClF2N6O7S2

• Molecular Weight:

  915.23

• References & Citations:

  [1]Merianda TT, et al. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol Cell Neurosci. 2009 Feb;40 (2) :128-42.|[2]Adiki Raja Sekhar, et al. A cell-permeant small molecule for the super-resolution imaging of the endoplasmic reticulum in live cells. Org Biomol Chem. 2019 Apr 10;17 (15) :3732-3736.|[3]Tanuja T Merianda, et al. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol Cell Neurosci. 2009 Feb;40 (2) :128-42.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported