ER-Tracker Blue-White DPX (solution)

• Description:

  ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K+ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation[1].Solvent and concentration: DMSO: 1 mM

• Target:

  Fluorescent Dye

• Related Pathways:

  Others

• Field of Research:

  Others

• Smiles:

  O=S(C(C=C1)=CC=C1C(O2)=NC=C2C3=CC=C(N(C)C)C=C3)(NCCNC(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O

• Molecular Formula:

  C26H21F5N4O4S

• Molecular Weight:

  580.53

• References & Citations:

  [1]Tanuja T Merianda, et al. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol Cell Neurosci. 2009 Feb;40 (2) :128-42.|[2]Corryn E Chini, et al. Observation of endoplasmic reticulum tubules via TOF-SIMS tandem mass spectrometry imaging of transfected cells. Biointerphases. 2018 Feb 26;13 (3) :03B409.|[3]Yun-Mi Jeong, et al. CDy6, a photostable probe for long-term real-time visualization of mitosis and proliferating cells. Chem Biol. 2015 Feb 19;22 (2) :299-307.|[4]Merianda TT, et al. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol Cell Neurosci. 2009 Feb;40 (2) :128-42.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20°C for 1 year, protect from light. Avoid repeated freezing and thawing

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  287715-95-1