PF-06761281

• UNSPSC Description:

  PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 μM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively[1].

• Target Antigen:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pf-06761281.html

• Purity:

  99.32

• Solubility:

  H2O : ≥ 50 mg/mL

• Smiles:

  O=C(O)[C@](CCC1=CC(C)=CN=C1OC)(O)CC(O)=O

• Molecular Weight:

  283.28

• References & Citations:

  [1]Huard K, et al. Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem. 2016 Feb 11;59(3):1165-75.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1854061-19-0