ACY-957

• Description :

  ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  HDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/ACY-957.html

• Purity :

  99.63

• Solubility :

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N

• Molecular Formula :

  C24H23N5OS

• Molecular Weight :

  429.54

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11 (4) :e0153767.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC2; HDAC3

• CAS Number :

  [1609389-52-7]