ACY-957

• UNSPSC Description:

  ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9[1].

• Target Antigen:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ACY-957.html

• Purity:

  99.66

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N

• Molecular Weight:

  429.54

• References & Citations:

  [1]Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1609389-52-7