BM 957

• Description:

  BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, IC50s of 5.4, 6.0 nM respectively.

• UNSPSC:

  12352005

• Target:

  Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/BM_957.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C(C)N(CC)C(C2=CC=C(Cl)C=C2)=C1C3=CC=CC(N4CCN(C5=CC=C(NS(=O)(C6=CC=C(N[C@H](CCN7CCC(O)CC7)CSC8=CC=CC=C8)C(S(=O)(C(F)(F)F)=O)=C6)=O)C=C5)CC4)=C3)O

• Molecular Formula:

  C52H56ClF3N6O7S3

• Molecular Weight:

  1065.68

• References & Citations:

  [1]Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55 (19) :8502-14.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bcl-2; Bcl-xL

• CAS Number:

  [1391107-54-2]