BM 957

• Description :

  BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, IC50s of 5.4, 6.0 nM respectively.

• UNSPSC :

  12352005

• Target :

  Bcl-2 Family

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/BM_957.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=C(C)N(CC)C(C2=CC=C(Cl)C=C2)=C1C3=CC=CC(N4CCN(C5=CC=C(NS(=O)(C6=CC=C(N[C@H](CCN7CCC(O)CC7)CSC8=CC=CC=C8)C(S(=O)(C(F)(F)F)=O)=C6)=O)C=C5)CC4)=C3)O

• Molecular Formula :

  C52H56ClF3N6O7S3

• Molecular Weight :

  1065.68

• References & Citations :

  [1]Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55 (19) :8502-14.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Bcl-2; Bcl-xL

• CAS Number :

  [1391107-54-2]