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BM 957

CAT: 0804-HY-18106Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18106Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, IC50s of 5.4, 6.0 nM respectively.
CAS Number
[1391107-54-2]
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BM_957.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)N(CC)C(C2=CC=C(Cl)C=C2)=C1C3=CC=CC(N4CCN(C5=CC=C(NS(=O)(C6=CC=C(N[C@H](CCN7CCC(O)CC7)CSC8=CC=CC=C8)C(S(=O)(C(F)(F)F)=O)=C6)=O)C=C5)CC4)=C3)O
Molecular Formula
C52H56ClF3N6O7S3
Molecular Weight
1065.68
References & Citations
[1]Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55 (19) :8502-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL

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