IACS-9571

• Description:

  IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

• Product Name Alternative:

  ASIS-P040

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/IACS-9571.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S (C1=CC=C (OC) C (OC) =C1) (NC2=C (OC3=CC (OCCC) =CC (OCCCCN (C) C) =C3) C=C (N4C) C (N (C) C4=O) =C2) =O

• Molecular Formula:

  C32H42N4O8S

• Molecular Weight:

  642.76

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59 (4) :1440-54.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1800477-30-8