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ACY-775

CAT: 0804-HY-19328-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19328-01Size:5 mg
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Description
ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM[1][2]. ACY775 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) [3].
CAS Number
[1375466-18-4]
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ACY-775.html
Purity
99.71
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NO)C(C=N1)=CN=C1NC2(CCCCC2)C3=CC=CC(F)=C3
Molecular Formula
C17H19FN4O2
Molecular Weight
330.36
Precautions
H228, H315, H319
References & Citations
[1]Veronick Benoy, et al. Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease. Neurotherapeutics. 2017 Apr; 14 (2) : 417-428.|[2]Jeanine Jochems et al. Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability. Neuropsychopharmacology. 2014 Jan; 39 (2) : 389-400.|[3]Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6

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Alternative Products

CatalogName
TQ0074-01ACY-775
A12456-10ACY-775 10mg
A12456-25ACY-775 25mg
A12456-2ACY-775 2mg
A12456-100ACY-775 100mg
A12456-5ACY-775 5mg
A12456-50ACY-775 50mg
A12456-200ACY-775 200mg
A12456-10mM-DACY-775 10mM * 1mL in DMSO
T30283-01B 775

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