FXR agonist 3

• Target :

  FXR|||Others

• Related Pathways :

  Metabolism|||Others

• Purity :

  0.9504

• Bioactivity :

  FXR agonist 3 is an anti-NASH compound with antifibrotic and anti-fibrotic activity, inhibiting the expression of COL1A1, TGF-?1, ?-SMA, and TIMP1, with an IC50 value of 8.19 ?mol/L for COL1A1. FXR agonist 3 ameliorates CDAHFD and BDL-induced liver injury in vivo by activating FXR.

• Smiles :

  COC1=CC2=C(C=C1OC)CC[N+]3=C2C=C4C(C(OCC5=CC=CC(C)=C5)=C(OC)C=C4)=C3.[Br-]

• Molecular Formula :

  C28H28BrNO4

• Molecular Weight :

  521.12

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C